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Transplantation

Adrian P. Ireland B.A.(mod), M.B. , M.Ch., FRCS(I).

Transplantation is the movement of an organ or tissue to another location.

Contents
List of Tables
List of Figures
Introduction
- Basic definitions
History of transplantation
- Timeline
- People in transplantation
Models used to study transplantion
- Mice
- Cats
- Dogs
- Rabbits
- Hamsters
- Humans
Immune response to transplantation
- First and second set response
- Tenets of transplantation immunology
- Genes responsible for rejection
- Major Histocompatibiliy Complex/Human Leucocyte Antigens
- Minor Histocompatibility Complex
- Cells of the immune response
  - Antigen presenting cells
  - T cells
- Basis of rejection
  - Allogenic recognition
- Patterns of rejection
Causes of end stage renal failure
Renal replacement therapy
Problems in people on long term dialysis
- Amyloidosis
- Acquired cystic disease
Organisation of the renal transplant team
- What happens when a potential donor is identified?
The donor
- Selection criteria for donors
- Medical history of the donor
- Blood tests on the donor
Multi organ retrieval
- Sequence of retreival
- Initial incision
- Cannulation of great vessels
- Heart and lung retreival
- Liver retreival
- Pancreatic retreival
  - Sequence of pancreatic retreival
  - Summary of pancreatic retreival
- Kidney retreival
Selection of the patient for renal transplantation
- End stage renal failure
- Similar tissue type
Transplantation of the kidney
- Prepartion of the donor kideny
- Insertion of the donor kidney
- Variations on the theme
Drugs
- Immunosupressant drugs
- Compliance with immunosuppressant therapy
- Anti viral therapy
- Recombinant Erythropoietin
Care of the patient post renal transplantion
- An immunosuppressant regimen
Important facts and figures
- Rate of development of end stage renal failure
- Rate of transplantation
- Survival rate of renal transplants, people post transplantation and in those on dialysis
- Complications
Does renal transplantation improve quality of life?
Glossary
- Allograft
- Autograft
- Isograft
- Major Histocompatibility Complex
- Minor Histocompatibility Complex
- Organ
- Syngraft
- Tissue
- Xenograft
Abbreviations
Bibliography
Index

Adrian P. Ireland