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Zinkernagel
R. M. Zinkernagel and P. C. Doherty discovered in 1974 that T cells will
only generate a response to viral antigen when it is presented on the surface
of cells in association with self MHC antigen. [ZD74]
This research culminated in the award of the Nobel
prize in physiology and medicine in 1996.
Adrian P. Ireland