Endothelial selectin, CD62E, is felt to be responsible for really slow rolling at a
speed of less than 5 mm s-1. It may play a role in the onset
of firm adhesion. It is expressed exclusively in activated endothelium.
E-selectin transcription and expression may be induced in vitro by endotoxin,
IL-1
and TNF-
. The gene product is detectable within an hour of
activation and reaches maximal levels in four to eight hours. It gradually
disappears from the cell surface over twelve to twenty-four hours.
E-selectin uses L-selectin on leucocytes as a counter receptor. Binding of Neutrophils to E-selectin results in a greater avidity of ICAM-1/2/3 on the endothelial cell for CD11/CD18 (Mac-1, LFA-1).