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Figure 3:
Schematic representation of the stages
of migration of leucocytes from the circulation to an area of injury
observable on microscopy. a) denotes the normal situation. In b) the
leucocytes are seen to roll along the endothelium, they appear `sticky'. In c)
the leucocytes are tightly adherent to the endothelium and in d) they migrate
through the endothelium into the interstium. In the transmigration stage there
are gaps formed between the endothelial cells and in the underlying basment
membrane.
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One of the responses of the body to injury is to recruite leucocytes to the
site of injury.
The accumulation of leucocytes in damaged tissues depends upon the interaction
of leucocytes with the endothelium in the damaged tissue, see
figure 3. There is a continuum between the stages of
rolling, adherence and transmigration.
Most of the manifestations of inflammation in a tissue, (leucocyte
accumulation, filtration of fluid and protein) only occur in the post
capillary venule.
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Adrian P. Ireland
