Biliary System

Last updated (28 October 2003)

No stone? Click on the image to download a larger version
The gallbladder has been removed from the patient.
What do you notice?
There is macroscopic evidence of cholesterosis of the gallbladder
The gall bladder was perforated during excision
The operative findings confirm the radiological diagnosis of acalculous cholecystitis
The gallbladder wall appears of normal thickness

The answer

The gallbladder has been removed intact, the image on the right shows the gallbladder opened. There are in fact gallstones present, two are seen sitting on the gallbladder mucosa. The gallbladder wall appears markedly thickened in keeping with cholecystitis. There are multiple white plaques present which represent cholesterolosis of the gallbladder wall.

What the student may say

I can see an intact gallbladder on the left, the superficial blood vessels appear injected suggesting inflammation.

To the right the gallbladder has been opened, two 4 mm gallstones are sitting in the gallbladder. The gallbladder wall is thickened and numerous white plaques which are typical of cholesterolosis are visible.

The white appearance is due to the accumulation of large amounts of cholesterol in foamy macrophages.

Contributing factors to missing the gallstones on ultrasound may have been the fact that they are small and few in number.

Small print

Cholesterolosis is a curiosity that may be seen upon opening the gallbladder in patients with cholecystitis. It does not have any particular significance. Most surgeons would routinely send an excised gallbladder for histological examination. Recently, some have questioned this as a waste of money and resources and suggest that only suspicious gallbladders should be submitted. Histological examination would be particularly important if there was any evidence of macroscopic abnormalities.

There is no evidence of perforation of the gallbladder on the left. It appears inflated with bile, etc. If a perforation does occur, gallstones may spill into the peritoneal cavity and if they are not retrieved they may subsequently cause trouble.

The operative finding agree nicely with the radiological diagnosis of cholecystitis, the gallbladder wall is thickened and there is cholesterolosis. But, the operative findings show gallstones which were missed on the ultrasound. Therefore the patient did not suffer acalculous cholecystitis. Ultrasound is a good test, however, no test is 100% accurate, there will be the occasion when it is wrong. In this particular patient, the fact the gallstones are small and few in number possibly contributed to the inaccuracy of ultrasound.

The gallbladder wall appears markedly thickened on this image.


Adrian P. Ireland