These inlcude IL-1, IL-2, IL-6, IL-8 and TNF-. Administration of antagonists to these agents such as IL-1ra (IL-1 receptor antagonist), or monoclonal antibodies against TNF- and soluble TNF-receptor block acute and chronic inflammatory responses in animal models of inflammatory disease.
IL-1 and TNF- are the main mediators involved in endotoxic shock.
Up regulation of the inflammatory response is also effected by IL-11, IF- and by members of the chemokine superfamily.
Production of pro-inflammatory cytokines is reduced by the anti-inflammatory cytokines (IL-4, IL-10, IL-13). And, production of IL-1, IL-6 and TNF- is inhibited by TGF-.