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Release of active agents

The lipooxygenase pathway product of arachadinoic acid leucotriene-B4 (LTB4), is released by activated leucocytes, it is a potent chemoattractant and induces ahesion and trans migration in venules.

Tumor necrosis factor-$\alpha $ (TNF-$\alpha $) is one of the most pro-inflammatory cytokines known. It is produces by the activated leucocyte.

Elastase, collagenase and gelatinase are released, these play a role in making a hole in the basement membrane to permit transmigration of leucocytes. They also function to degrade the interstitial matrix.

Adrian P. Ireland