Adenomas:

Adenomas may be found in; the stomach, duodenum, small bowel, hepatobiliary system, adrenal and pancreas. Cancer may develop at these sites.

Gastric adenomas are seen in about 10% of patients with FAP . They have a lower malignant potential than duodenal polyps but there is a malignant predisposition. Regular endoscopic examination with biopsy is advised.

Duodenal polyps are seen in almost all patients with FAP . They are most common around the ampulla and this may be related to the relationship of the ampullary region to the release of bilio-pancreatic secretions. The extent of duodenal polyposis is variable, and is severe in 10% or patients. Some patients need to be considered for pancreatico-duodenectomy.