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Amsterdam Criteria

These criteria are used to help identify patients who may have HNPCC. Such patients should be considered for screening. The Amsterdam I criteria, see table 3 were considered too restrictive and were modified in 1999, see table 4. A patient is considered positive for the Amsterdam criteria if they match either set of criteria.

While the tables are difficult to remember exactly, they state what one may imagine from basic principles, several members of the family affected by the tumors, and young age at diagnosis.


Table 3: The first set of Amsterdam criteria, Amsterdam I 1990, for the diagnosis fo HNPCC
At least 3 relatives with colorectal cancer, one of whom shold be a first degree relative of the other two
At least two successive generations should be affected
At least one colorectal cancer shold be diagnosed before age 50 years
FAP should be excluded
Tumors should be verified by pathological examination


Table 4: The second set of Amsterdam criteria, Amsterdam II 1999, for the diagnosis of HNPCC
At least 3 relatives with an HNPCC-associated cancer

Colorectal

Endometrial

Small Bowel

Ureter

Renal Pelvis

One of these relatives should be a first degree relative of the other two.

At least two succesive generations should be affected
At least one should be diagnosed before the age of 50 years
FAP should be excluded in the colo-rectal cancer case(s) if any
Tumors should be verified by pathological examination


next up previous index Surgical Topics
Next: Extracolonic Manifestations of HNPCC Up: Lynch syndrome (HNPCC) Previous: Lynch syndrome (HNPCC)   Index
Adrian P. Ireland