The Skin

Last updated (19 November 2003)

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The punch biopsy shows that the lesion is in fact a squamous cell cancer. What is the most appropriate next step?
Send the patient for radiotherapy
Do an MRI
Send the patient for chemotherapy
Organise excision and reconstruction

The answer

This lesion is best treated by excision and reconstruction.

The student may say

I would ensure that the history has been taken and that a full clinical examination has been performed.

I would double check the histological results to ensure that they belong to the patient then I would meet with the patient (and his family if he wished) to discuss the diagnosis and make plans for further treatment. This meeting should ideally happen in private and with a senior member of the surgical team.

The best option in this situation would be surgical excision and reconstruction. Radiotherapy can be considered for squamous cancers, but the location of this lesion close to the eye would make protection of the eye from the harmful effects of radiation difficult. Topical therapy in the form of fluro-uracil would probably not confirm much benefit in an advanced lesion such as this and systemic chemotherpay offers little benefit.

I would recommend to the patient that he consider surgical excision with reconstruction.

I think that on the first discussion it would not be appropriate to go into details regarding the procedure, the risks involved etc, however, if the patient wanted to discuss this I would have a full discussion with him.

Small print

Radiotherapy can be used for skin squamous cancers, often with good results, however this lesion on the temple is close to the eye and radiotherapy may cause cataract and blindness when used to treat a neoplasm in this location.

MRI scanning has no role to play at this juncture. If you want to treat the patient differently if you find MRI evidence of metastatic disease then MRI may be reasonable but most would treat the patients primary cancer and follow them up clinically to see what happens.

Chemotherapy in the form of 5 fluro-uracil cream is used to treat carcinoma in situ of the skin but is not very useful in large lesions. Similarly systemic chemotherapy is not routinely used due to a poor response.


Adrian P. Ireland