TGF-

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TGF- $\ensuremath {\beta }$

TGF- $\ensuremath {\beta }$ is a mixed effect cytokine. It may have both pro and anti inflammatory effects.

As outlined above TGF- $\ensuremath {\beta }$ inhibits the production of most monokines and lymphokines. In this respect it is anti-inflammatory by reduction in release of IL-1, IL-6 and TNF- $\ensuremath{\alpha}$ .

TGF- $\ensuremath {\beta }$ besides its anti-inflammatory effects is pro inflammatory. It acts as a chemoattractant for neutorphils, T cells and unactivated monocytes.

Systemic TGF- $\ensuremath {\beta }$ is anti-inflammatory while local TGF- $\ensuremath {\beta }$ is pro-inflammatory. It has an important role to play in scar formation and promotes neo-vascularisation and proliferation of connective tissue cells.

Adrian P. Ireland