Heparinisation

Start with a bolus of 5,000 IU, and 1,000 IU/hr infusion after that. Check coagulation 6 hours later.

• If APTT is $<$ 70 seconds, increase heparin by 100 IU/hr.
• If APTT is between 70-100 seconds, maintain the same dose.
• If APTT is between 100-120 seconds, decrease heparin by 100 IU/hr.
• If APTT is $>$ 120 seconds, stop for 2 hours, recommence at 100 IU/hr lower than previous dose
• Repeat Coag 4-6 hours after changing heparin dose.

Heparin can-be reversed by Protamine Sulphate or infusion of fresh frozen plasma (there is a risk of anaphylaxis when using protamine sulphate)

Only reverse heparin in consultation with Senior Team Member