LFA-1, CD11a/CD18

Lymphocyte function associated antigen-1 (LFA-1), the predominant $\beta _2$ integrin is critical to transmigration of neutrophils and is important for transmigration of other leucocytes. In vivo both CD11a and CD11b (Mac-1) mono-clonal antibodies reduce inflammation. This shows some redundancy between the functions of both LFA-1 and Mac-1. However, CD11b antibodies do not stop transmigration and CD11b knockout mice do not show defective transmigration.