VCAM-1

Vascular cell adhesion molecule one, VCAM-1 (CD106) weighs 100 to 110 Kd and is located on endothelial cells. It is the ligand for VLA-4, a $\beta_1$ integrin expressed on leucocytes. Expression of VCAM-1 increases adhesion of lymphocytes, monocytes, eosinophils and basophils. Melanoma cells use VCAM-1 to adhere to the endothelium and VCAM-1 appears to play a role in the recruitment of monocytes to atherosclerotic plaque.